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人类感染的普马拉病毒(PUUV)为中欧最为常见汉坦病毒,主要引起流行性肾病(NE),其主要表现为急性肾损伤和血小板减少。为了确定汉坦病毒感染患者的临床表现、长期预后和对PUUV的体液免疫反应,在2001—2012年期间,我们对456名德国病人进行了一项横断面的前瞻性调查,所有患者均为临床和血清学方法确诊的汉坦病毒相关NE。NE急性期突出的临床表现为发热和背部/肢体疼痛,88%患者有急性肾损伤。在随访期间(7~35月),全部病人都可以检测出汉坦病毒特异性IgG
Human infected Pura virus (PUUV) is the most common hantavirus in Central Europe and predominantly causes nephropathy (NE), which is mainly manifested as acute kidney injury and thrombocytopenia. To determine the clinical presentation, long-term prognosis, and humoral immune response to PUUV in patients with Hantavirus infection, we conducted a prospective cross-sectional survey of 456 German patients between 2001 and 2012, all of whom were clinically And hantavirus-associated NE diagnosed by serological methods. Outstanding clinical manifestations of acute phase NE were fever and back / limb pain, 88% of patients had acute kidney injury. During follow-up (July-May), all patients were able to detect Hantavirus-specific IgG