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耶尔森氏菌属中有3个种对人和动物具有致病性,包括鼠疫杆菌(Yersinia pestis)、小肠结肠炎耶尔森氏菌(Yersinia enterocolitica)和假结核耶尔森氏菌(Yersinia pseudotuberculosis)。研究发现,假结核耶尔森氏菌能通过小鼠小肠派氏淋巴结的M细胞(Microfold cell)进行跨细胞转运。这种转运方式首先是细菌利用其表面蛋白侵袭素Invasin或黏附素Yad A蛋白识别并结合宿主细胞表面的整合素Integrin受体家族成员的β1链,然后细胞膜上的分泌通道打开,细菌利用Ⅲ型分泌系统把效应蛋白注入宿主细胞内,破坏宿主细胞免疫系统进行感染的过程。过去三十年内关于假结核耶尔森氏菌有大量的文献报道,本文综述该菌与宿主细胞之间相互作用分子机制的研究进展,并讨论目前关于假结核耶尔森氏菌的研究方向及热点。
Three species of Yersinia are pathogenic to humans and animals, including Yersinia pestis, Yersinia enterocolitica, and Yersinia pseudotuberculosis). The study found that Yersinia pseudotuberculosis transmembrane transport through M lymphocytes (Microfold cell) of mouse intestinal lymph nodes. This transport mode first bacteria use its surface protein invasion Invasin or adhesin Yad A protein recognition and binding to integrin receptor family members of the host cell surface β1 chain, and then the secretion of the cell membrane on the open, the bacteria using type Ⅲ The secretion system injects effector proteins into host cells, destroying the host’s cellular immune system for infection. In the past three decades, there have been a large number of literature reports on Yersinia pseudotuberculosis. This article reviews the research progress on the molecular mechanism of the interaction between the bacteria and host cells and discusses the current research directions on Yersinia pseudotuberculosis and Hot spots.