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目的探讨孕妇血浆生长分化因子-15(plasma growth differentiation factor-15,GDF-15)在妊娠期高血压疾病中的预测和诊断价值。方法选择2014年7月至2016年6月在海门市人民医院就诊及住院分娩的妊娠期高血压疾病孕妇137例,包括妊娠期高血压61例,轻度子痫前期28例,重度子痫前期27例,慢性高血压21例。另有同期在我院产前检查及住院分娩的正常单胎孕妇120例。所有正常孕妇及各组妊娠期高血压疾病孕妇分别按孕20周前、20~27周、28~35周、36周后再分组并测定GDF-15比较分析。结果子痫前期组GDF-15水平高于妊娠期高血压组、慢性高血压组以及正常孕妇组,重度子痫前期组高于轻度子痫前期组,差异均有统计学意义(P<0.05)。重度子痫前期组中,孕36周后组GDF-15水平显著高于孕20周前组、20~27周组、28~35周组,差异有统计学意义(P<0.05);轻度子痫前期组、妊娠期高血压组、慢性高血压组各孕期GDF-15水平差异无统计学意义(P>0.05)。结论 GDF-15可能是妊娠期高血压疾病严重程度的潜在预测因子。
Objective To investigate the predictive and diagnostic value of plasma growth differentiation factor-15 (GDF-15) in pregnancy-induced hypertensive disorders. Methods From July 2014 to June 2016, 137 pregnant women with gestational hypertension who received medical treatment and in hospital were included in this study. Among them, there were 61 pregnant women with gestational hypertension, 28 with mild preeclampsia and 28 with severe preeclampsia 27 cases, 21 cases of chronic hypertension. Another in the same period in our hospital prenatal care and hospital delivery of normal singleton pregnant women 120 cases. All normal pregnant women and pregnant women with gestational hypertension in each group were divided into groups according to GDF-15 level before 20 weeks, 20-27 weeks, 28-35 weeks and 36 weeks after pregnancy. Results The level of GDF-15 in preeclampsia group was higher than that in gestational hypertension group, chronic hypertension group and normal pregnant women group, and severe preeclampsia group was higher than that in mild preeclampsia group (P <0.05 ). In the severe preeclampsia group, the level of GDF-15 in the 36th week pregnant group was significantly higher than that of the pre-20th week pregnant group, 20-27 week group and 28-35 week pregnant group (P <0.05), mild The levels of GDF-15 in preeclampsia group, gestational hypertension group and chronic hypertension group were not significantly different (P> 0.05). Conclusion GDF-15 may be a potential predictor of the severity of gestational hypertension.