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目的探讨2型糖尿病肾病(DN)早期患者血清胱抑素C(CysC)水平的变化及临床诊断价值。方法分析我院收治的214例2型糖尿病患者,根据患尿清蛋白排泄率UAER分为糖尿病早期肾病组(DN)组114例,UAER>20μg/min,糖尿病无肾病组(DM)组100例,UAER<20μg/min,比较两组CysC、FPG、2hPG、BUN水平。结果两组患者在CysC水平比较,差异具有统计学意义(P<0.05),在FPG、2hPG、BUN水平变化比较差异不具有统计学意义(P>0.05)。结论血清CysCs检测可作为诊断DN早期肾损伤的有效指标,可应用于2型糖尿病患者DN进展监测。
Objective To investigate the changes of serum cystatin C (CysC) level in early stage of type 2 diabetic nephropathy (DN) and its clinical value. Methods 214 patients with type 2 diabetes mellitus were enrolled in our hospital. According to the urinary albumin excretion rate (UAER), 114 cases were divided into diabetic nephropathy group (DN), UAER> 20μg / min and diabetic nephropathy group (DM) , UAER <20μg / min, CysC, FPG, 2hPG, BUN levels were compared between the two groups. Results The difference of CysC between the two groups was statistically significant (P <0.05). There was no significant difference in the levels of FPG, 2hPG and BUN between the two groups (P> 0.05). Conclusion Serum CysCs detection can be used as an effective index for diagnosis of DN early renal injury and can be applied to DN progression monitoring in type 2 diabetic patients.