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目的重型β地中海贫血患者长期进行输血治疗,出现过多的铁负荷,观察除铁灵对重型β地中海贫血的驱铁效果。方法选取经确诊为重型β地中海贫血患者28例进行观察,随机分为对照组12例与治疗组16例,对照组患者采取输血治疗;治疗组患者在进行输血治疗的同时,结合除铁灵进行治疗,经过联合治疗,检查患者血液中血清蛋白以及患者的肝功能情况,并且对患者的生长发育情况进行详细的观察。结果重型β地中海贫血患者经过长期的输血治疗,血液中的铁含量明显比正常范围要高,导致患者出现明显的铁负荷,结合除铁灵治疗之后,患者血液中的血清铁蛋白含量明显下降,与治疗前相对比,具有明显差异,有统计学意义(P<0.05)。结论对重型β地中海贫血进行输血以及除铁灵结合治疗,能够有效治疗患者血液中铁负荷过多的症状,疗效明显、安全,并且没有出现明显的毒副反应,具有良好的临床价值,值得推广。
Objective To investigate the long-term blood transfusions of patients with β-thalassemia major who have excessive iron overload and to observe the effect of iron removal on iron-deficiency β-thalassemia. Methods Twenty-eight patients diagnosed with severe β-thalassemia were selected and randomly divided into control group (n = 12) and treatment group (n = 16), while patients in control group received transfusion therapy. Patients in treatment group Treatment, after treatment, check the patient’s blood serum protein and liver function of patients, and the patient’s growth and development were observed in detail. Results After long-term blood transfusions in patients with severe β-thalassemia, the iron content in the blood was obviously higher than the normal range, leading to significant iron load in patients. After treatment with dextromethorphan, the content of serum ferritin in the blood decreased significantly, Compared with before treatment, with significant differences, statistically significant (P <0.05). CONCLUSIONS: It is worth to popularize that the transfusion of blood and the combination of iron and spleen in treatment of severe β-thalassemia can effectively treat the iron overload symptoms in the blood of patients with obvious and safe curative effect and no obvious side effects.