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我国科学家运用全基因组关联分析方法,首次在汉族人群中发现两个宫颈癌遗传易感变异位点,这一成果发表在国际顶级专业期刊《自然-遗传学》上。华中科技大学同济医院12月16日举行新闻发布会,介绍了马丁教授带领的科研团队在宫颈疾病研究领域这一阶段性成果。宫颈癌是威胁妇女生命健康最严重的疾病之一,近年来呈现明显年轻化趋势,我国宫颈癌患者平均发病年龄比10年前年轻了5岁以上。高危型HPV病毒的持续感染是宫颈癌发病的主要风险因素,超过99%的病例均检测到HPV病毒感染。然而,临床研究发现,超过70%的女性一生中有过一次以上的一过性HPV感染,但只有极少数导致宫颈癌。
Chinese scientists, using genome-wide association analysis, discovered for the first time two susceptible loci in cervical cancer in the Han population. This result was published in the journal Nature-Genetics of the world’s top professional journals. Huazhong University of Science and Technology Tongji Hospital December 16 press conference to introduce the Martin Martin led the research team in cervical disease research in the field of this stage results. Cervical cancer is one of the most serious diseases that threaten women’s life and health. In recent years, cervical cancer shows an obviously younger trend. The average age of onset of cervical cancer in our country is over 5 years old than 10 years ago. Persistent infection with high-risk HPV is a major risk factor for cervical cancer, with HPV infection detected in more than 99% of cases. However, clinical studies have found that more than 70% of women have had more than one transient HPV infection in their lifetime, but only a very small number cause cervical cancer.