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急性髓系白血病(AML)M_(2b)是我所在50年代末根据形态学和临床特点提出的一个AML特殊亚型,该亚型已于1986年被正式纳入我国白血病分型方案。对于该亚型的临床表现、细胞化学染色、超微结构等已进行了较祥细的研究。初步的染色体核型分析表明AML-M_(2b)常有t(8;21)染色体易位。国际上于70年代从染色体异常的特点提出t(8;21)白血病。近几年来国外作者分别在21号和8号染色体断裂区发现
Acute myeloid leukemia (AML) M_(2b) is a special subtype of AML that I proposed in the late 1950s based on morphological and clinical characteristics. This subtype was officially included in the Chinese leukemia typing program in 1986. Subtle studies have been conducted on the clinical manifestations, cytochemical staining, and ultrastructure of this subtype. Preliminary karyotype analysis revealed that AML-M_(2b) often has t(8;21) chromosomal translocations. Internationally, t(8;21) leukemia was proposed from the characteristics of chromosome abnormalities in the 1970s. In recent years, foreign authors have discovered chromosome 21 and chromosome 8 respectively.