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目的通过研究社会互作奖赏剥夺对小鼠代谢性学习记忆的影响,为进一步探讨亲子关系、社会隔离、集体生活等社会互作活动与儿童摄食行为之间的关系提供理论基础和实验依据。方法共39只3月龄的雄性C57BL/6J小鼠随机分为群居组和独居组,然后分别进行能量偶联的条件性口味偏好训练。由于小鼠在建立口味偏好的训练过程中,为单只在单个饲养笼中进行,所以群居组小鼠的训练就模拟了社会互作奖赏剥夺,长期未体验社会互作奖赏效应(也不存在社会互作奖赏剥夺)的独居组为对照组。结果在未进行条件性口味偏好训练的前期选择测试过程中,社会互作奖赏剥夺组小鼠对仅具口味(尚无能量的意义)的溶液摄取量明显少于对照组小鼠(P<0.001),但对两种不同仅具口味的溶液摄取量无明显差别(P>0.05);以代谢性能量作为非条件刺激进行口味偏好训练后,社会互作奖赏剥夺小鼠和对照组小鼠都对能量偶联的口味溶液形成显著的偏好性(P<0.001),但是社会互作奖赏剥夺小鼠的能量偏好程度显著低于对照组小鼠(P<0.001)。整个训练过程中,小鼠的体重并无明显改变。结论社会互作奖赏剥夺显著影响小鼠的摄食行为,尤其对小鼠的代谢性的口味学习记忆造成显著影响。该研究提示,社会互作奖赏对于儿童正确摄食行为习惯的建立具有十分重要的作用。
The purpose of this study is to explore the relationship between social interactions and social behaviors such as parent-child relationship, social isolation and collective life, and to provide theoretical and experimental evidences for the relationship between social interaction and children’s feeding behaviors. Methods Thirty-nine 3-month-old male C57BL / 6J mice were randomly divided into social group and solitary group, and then conditioned on conditional energy preferences. Because mice were only trained in single cage during training to establish taste preferences, cohort mice training simulated deprivation of social interaction rewards and long-term failure to experience social reward rewards Social interaction reward deprivation) alone group as the control group. Results In the pre-selection test without conditioned taste preference training, the mice in the social interaction-reward-deprived mice had significantly less food intake than the control mice (P <0.001 for taste only (no energy meaning) ), But there was no significant difference (P> 0.05) in the intake of two different flavors only solutions; after the taste preference training with metabolic energy as a non-conditional stimulus, the mice in social deprivation and control mice There was a significant preference for the energy-coupled flavor solutions (P <0.001), but energy-deprivation in socially deprived mice was significantly lower than in control mice (P <0.001). The weight of the mice did not change significantly throughout the training. Conclusion Deprivation of social interaction reward significantly affects the feeding behavior of mice and especially has a significant effect on the metabolic taste learning and memory of mice. The study suggests that social interaction rewards play a very important role in the establishment of children’s correct eating habits.