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目的分析药源性肝损害的特点和规律,为临床用药提供参考。方法通过中国知网(CNKI)期刊数据库检索2012~2016年报道的药品引起药源性肝损害病例个案及药学监护文献,自行建立数据库,对文献资料进行整理、汇总,并进行分析。结果导致药源性肝损害的药品涉及13大类106种药品,分布较广,其中前两位是中药制剂及抗微生物类药品;用药后1个月以内发现肝损害占61.03%(83/136);2例死亡病例均为联合使用肝损害药物。结论严格用药指征,按照药品说明书的用量用法使用,避免联合使用肝损害药物,密切观察用药后反应,减少药源性肝损害的发生。
Objective To analyze the characteristics and rules of drug-induced liver injury and provide reference for clinical medication. Methods The cases of drug-induced liver damage caused by drugs reported in 2012-2016 were searched through the CNKI journal database, and the databases of their own were established. The data were collated, summarized and analyzed. As a result, drug-induced liver damage involved 106 drugs in 13 major categories, of which the first two were traditional Chinese medicine preparations and anti-microbial drugs. Liver damage was found in 61.03% within one month after treatment (83/136 ); 2 deaths were combined with liver damage drugs. Conclusions Strict indications for use, in accordance with the dosage instructions for the use of drug specifications to avoid the joint use of liver damage drugs, close observation of the reaction after medication to reduce drug-induced liver damage.