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本文是我院开展人类体外受精与胚胎移植技术研究的初步报道。1990年1～12月收治不孕妇女34例,42治疗周期,采用固定的 Fertilin/Pergonal/Profasi 超刺激排卵方案,B 型超声监测卵泡发育并指导经阴道取卵。每周期有6.97±4.1个卵泡发育,获得卵子4.7±4.6个,受精率为71％,卵裂率64％,移植率87.8％。每周期移植的胚胎总分与移植后妊娠率有显著相关性(r=0.8823,P=0.009),移植胚胎评分高,数量多,则妊娠率越高。在未建立胚胎冻存技术之前,4个以上的胚胎移植是处理过剩胚胎的权宜方法。本组大部分病人在门诊接受治疗,可减轻精神与经济负担。
This article is our hospital to carry out human in vitro fertilization and embryo transfer technology research report. Between January and December 1990, 34 infertile women and 42 cycles of treatment were treated. The fertilization program of Fertilin / Pergonal / Profasi was used to supervise ovulation. B-mode ultrasound was used to monitor follicular development and guide vaginal ovulation. 6.97 ± 4.1 follicles were developed per cycle, 4.7 ± 4.6 eggs were obtained, fertilization rate was 71%, cleavage rate was 64%, and transplantation rate was 87.8%. There was a significant correlation between the total score of embryos transplanted per week and the pregnancy rate after transplantation (r = 0.8823, P = 0.009). The higher the grafted embryos score and the larger the number, the higher the pregnancy rate. More than 4 embryo transfers are an appropriate way to deal with excess embryos until the embryo cryopreservation technique is established. Most patients in this group receive treatment at outpatient department, which can reduce the mental and financial burden.