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用放免法测定正常孕妇、妊娠高血压综合征(PIH)患者和胎儿血浆中心房钠尿肽(Atrial natriuretic peptide,ANP)、醛固酮(Aldosterone,Aldo)含量,观察ANP、Aldo与妊娠及PIH关系。孕妇孕中、晚期和产时血浆中ANP显著高于未孕妇女,PIH患者血浆中ANP显著高于孕妇和未孕妇女。ANP与妊娠病指数呈正相关;孕妇血浆中Aldo显著高于未孕妇女,PIH患者Aldo却显著低于孕妇;胎儿血浆中ANP、Aldo均高于母血,PIH胎儿ANP高于正常胎儿,Aldo显著低于正常胎儿。提示ANP高低与PIH病情严重程度相关,可作为预测PIH的指标之一;孕时Aldo分泌与胎儿-胎盘功能单位有关。
Atrial natriuretic peptide (ANP) and aldosterone (Aldosterone) contents in normal pregnant women, patients with pregnancy induced hypertension (PIH) and fetal plasma were measured by radioimmunoassay. The relationship between ANP, Aldo and pregnancy and PIH was observed. The levels of ANP in pregnant women in the second trimester, late pregnancy and delivery were significantly higher than those in non-pregnant women. The plasma levels of ANP in PIH patients were significantly higher than those in pregnant women and non-pregnant women. ANP and pregnancy disease index was positively correlated; pregnant women, the plasma Aldo was significantly higher than non-pregnant women, PIH patients Aldo was significantly lower than pregnant women; fetal plasma ANP, Aldo were higher than maternal blood, PIH fetus ANP higher than normal fetuses, Aldo significantly Lower than normal fetus. These results suggest that the level of ANP is related to the severity of PIH and can be used as one of the indexes for predicting PIH. The secretion of Aldo during pregnancy is related to fetal-placental function unit.