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目的观察具有健脾益气、调肝活血作用的糖肝宁合剂对高血糖合并CCL4所致慢性化学性肝损伤大鼠肝功能(ALT、AST)、SOD、MDA的影响,并探讨其作用机理。方法除正常组外,所有动物均制作高血糖大鼠,再用四氯化碳腹腔注射以造成肝损伤模型。同时将动物分为模型组、糖肝宁大剂量组、糖肝宁小剂量组组、降糖甲组,并予以相应的药物灌胃。灌胃3个月后检查大鼠肝功能、超氧化物歧化酶(SOD)、丙二醛(MDA)。结果糖肝宁合剂能显著改善高血糖合并CCL4所致慢性肝损伤大鼠异常的肝功能,SOD、MDA的水平。结论糖肝宁合剂能有效的防治高血糖合并四氯化碳所致慢性肝损伤大鼠的肝功能。其作用机制可能与抗氧化有关。
Objective To observe the effect of Tangganning Mixture with Jianpi Yiqi and Tiaogan Huoxue on liver function (ALT, AST), SOD and MDA in hyperglycemia combined with chronic liver injury induced by CCL4 in rats, and to explore its mechanism of action . Methods Except the normal group, all animals were made hyperglycemic rats and then injected with carbon tetrachloride intraperitoneally to induce liver injury model. At the same time, the animals were divided into model group, high-dose Tangganning group, low-dose Tangganning group, and hypoglycemic group A, and corresponding drugs were given to the stomach. Liver function, superoxide dismutase (SOD), and malondialdehyde (MDA) were examined after intragastric administration for 3 months. Results Tangganning Mixture can significantly improve the abnormal liver function, SOD, MDA levels in hyperglycemia patients with CCL4-induced chronic liver injury. Conclusion Tangganning Mixture can effectively prevent liver function in hyperglycemia rats with chronic hepatic injury induced by carbon tetrachloride. Its mechanism of action may be related to antioxidants.