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目的探讨布地奈德和干扰素吸入疗法治疗毛细支气管炎的临床疗效。方法选取毛细支气管炎患儿88例,随机分为治疗组和对照组,两组均采用相同综合治疗,治疗组加用布地奈德混悬剂和α1b干扰素空气压缩泵雾化吸入治疗,用法为布地奈德混悬剂1ml(含布地奈德0.5mg)加生理盐水至2ml,每次吸入10～15min,每日2次,疗程5d,干扰素α1b 10万U/(kg.d),加生理盐水配成2ml,每次10～15min,每日1次,疗程3d。观察两组症状体征持续时间、住院天数及临床疗效,治疗组缓解期长期布地奈德气雾剂吸入,观察喘息复发情况。结果治疗组哮鸣音消失、湿啰音消失、咳嗽消失时间及住院时间较对照组明显缩短(P<0.05),治愈率明显提高(P<0.05),缓解期喘息复发减少。结论布地奈德和干扰素吸入疗法治疗毛细支气管炎临床疗效肯定,安全无副作用,缓解期长期布地奈德气雾剂吸入可减少喘息发作,值得临床应用。
Objective To investigate the clinical efficacy of budesonide and interferon inhalation in the treatment of bronchiolitis. Methods 88 cases of children with bronchiolitis were randomly divided into treatment group and control group. Both groups were treated with the same combination therapy. The treatment group was treated with inhalation of budesonide suspension and α1b interferon air compression pump, For budesonide suspension 1ml (containing budesonide 0.5mg) plus saline to 2ml, each inhalation 10 ~ 15min, 2 times a day, the course of treatment 5d, interferon α1b 100000 U / (kg · d) Add saline 2ml, each 10 ~ 15min, 1 day, course of treatment 3d. The duration of symptoms and signs, days of hospitalization and clinical curative effect were observed in both groups. Long-term budesonide inhalation was given to the treatment group to observe the recurrence of wheezing. Results The disappearance of wheeze, disappearance of wet rales, disappearance of cough and hospital stay were significantly shorter than those in control group (P <0.05). The cure rate was significantly improved (P <0.05) and the remission was reduced during remission. Conclusion Budesonide and interferon inhalation therapy for the treatment of bronchiolitis clinical effect is sure, no safety and side effects, long-term budesonide inhalation inhalation can reduce wheezing, it is worth clinical application.