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目的通过连续8年监测黄陵县病区儿童头发中锌、铜、铁、锰、硒和钙等元素的含量,以探讨病区儿童发中锌、铜、铁、锰、硒和钙水平的动态变化及与克山病病情的可能关联。方法在黄陵县6个重病村设立监测点,全体居民均为检测对象。1996-2003年连续8年对该检测点克山病的发病情况及3-15岁儿童发中锌、铜、铁、锰、硒和钙元素水平进行检测。结果病区儿童锌、铜含量各观察点及非病区间均无明显差异,病区河腰、案角村儿童发铁、锰含量均高于厚子坪村儿童,其中发铁亦显著高于非病区儿童;病区儿童发硒含量8年均达到非病区水平,所有观察元素均无明显的年度差异。结论病区儿童所测元素均无明显的年度变化,发硒已达到非病区水平,发锌、铜接近非病区水平,病区儿童发铁的高水平及其在克山病发病学中的意义值得进一步研究。
Objective To monitor the levels of zinc, copper, iron, manganese, selenium and calcium in the hair of children in Huangling County ward for 8 years in a row to explore the levels of zinc, copper, iron, manganese, selenium and calcium in children’s ward Dynamic Changes and Possible Correlation with Keshan Disease. Methods Six monitoring sites were set up in 6 seriously ill villages in Huangling County. All the residents were tested. The incidence of Keshan disease and the levels of zinc, copper, iron, manganese, selenium and calcium in children aged 3-15 years were examined for the eight consecutive years from 1996 to 2003. Results There was no significant difference in Zinc and Copper contents between observation points and non-disease areas in children in Ward. The children’s iron and manganese contents in river and waist areas and cases in Fangjiao Village were higher than those in Houso Village, Ward children; ward children selenium content of eight years reached the level of non-ward, all the observed elements were no significant annual differences. Conclusions There is no obvious annual change in the measured elements of children in the ward. Selenium has reached the level of non-ward, hair zinc, copper close to the non-ward level, the high level of iron in ward children and its incidence in Keshan disease The significance of further study.