血管内皮生长因子C与人类表皮生长因子-2在人类乳腺癌中表达的相关性研究(英文)

• 作 者: Shuxian Qu Zhendong Zheng Zhaozhe Liu Liang Liu Miao Zhang Yaling Han Xiaodong Xie
• 机 构: Department of Oncology, The General Hospital of Shenyang Military Region,Department of Oncology, The
• 出 处: The Chinese-German Journal of Clinical Oncology
• 发表日期: 2004年期
• 关键词: assessed 乳腺癌 表皮生长因子 prognosis metastasis malignancy 英文 axillary aimed cytoplasm

Objective: We aimed to study the transcription level of VEGF-C in human breast cancer tissue, and explore the correlations with the expression of C-erbB-2. Methods: The expression of VEGF-C mRNA in 51 cases of human breast cancer was assessed by hybridization in situ. The expressions of C-erbB-2 was assessed by immunohistochemistry. Results: The positive rate of VEGF-C mRNA was 54.9% in 51 cases of breast cancer. The transcription level had correlation with tumor size and status of lymph nodes(P < 0.05). The expression of VEGF-C mRNA had a positive correlation with the expression of C-erbB-2(P < 0.05). Conclusion: The up-expression of VEGF-C has a significant correlation with the malignancy level and clinical stage of breast cancer. The combined detection of VEGF-C, C-erbB-2 may help to estimate the prognosis of patients with breast cancer and study on thetherapeutic implications.

Objective: We aimed to study the transcription level of VEGF-C in human breast cancer tissue, and explore the correlations with the expression of C-erbB-2. Methods: The expression of VEGF-C mRNA in 51 cases of human breast cancer was The expression of C-erbB-2 was assessed by immunohistochemistry. Results: The positive rate of VEGF-C mRNA was 54.9% in 51 cases of breast cancer. The transcription level had correlation with tumor size and status of lymph node (P <0.05). The expression of VEGF-C mRNA had a positive correlation with the expression of C-erbB-2 The combined detection of VEGF-C, C-erbB-2 may help to estimate the prognosis of patients with breast cancer and study on the therapeutic implications.