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新多聚物的利用促进按零级动力学过程释放药物的治疗体系(TS)的发展。在各种片剂工艺中,从机械设备、工艺控制等方面考虑,直接压片法是最为可靠的一种方法,故已被推荐于药物TS 的制备。多聚物压片时的物理工艺学特性不同于通常的结晶物质。为搞清直接压片法制备TS 时的特性,本文研究一系列多聚物例如纤维素,丙烯-、乙烯-、聚乙烯-和聚丙烯衍生物的可压性,以压力-位移周期(Force-displacement cycle)作为评价这些物质可压性的指标。容易压缩的结晶物质在压片进程中,粉床体积的减小,至少存在三个阶段。第一阶段为粉粒间大小如粒子
The use of new polymers promotes the development of therapeutic systems (TSs) that release drugs in a zero-order kinetic process. In various tablet processes, direct compression is one of the most reliable methods in terms of mechanical equipment, process control and the like, and therefore it has been recommended for the preparation of drug TS. The physical and chemical properties of the polymer pellets differ from the usual crystalline materials. In order to understand the properties of TS prepared by direct compression method, this paper studies the compressibility of a series of polymers such as cellulose, propylene-, ethylene-, polyethylene- and polypropylene derivatives, the pressure-displacement period -displacement cycle as an indicator of the compressibility of these substances. Easy compression of the crystalline material in the tableting process, powder bed volume reduction, there are at least three stages. The first stage for the particle size between particles such as particles