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目的：探讨“参素酶合剂”对婴幼儿重症肺炎并充血性心力衰竭的治疗作用。方法：重症肺炎并充血性心力衰竭患儿１０２例，随机分为“参素酶合剂”治疗组５１例和对照组５１例。对照组采用常规综合治疗。治疗组在综合治疗的基础上，加用丹参注射液（出生～３个月者每次２ｍｌ，１～２岁者每次５ｍｌ）及维生素Ｃ（３００～５００ｍｇ·ｋｇ－１／ｄ）分别静滴；并加辅酶Ｑ１０１片口服，每日３次。结果：两组症状、体征恢复正常的时间均有显著性差异。两组呼吸频率、心率与肝脏肿大恢复正常的时间分别为１．５７２±０．１０１天比５．１７６±０．４３５天（Ｐ＜０．００１），１．７０９±０．１３７天比４．３００±０．３９６天（Ｐ＜０．００１）和１．５７７±０．１５６天比７．５００±０．７２５天（Ｐ＜０．００１）。两组治疗前后分别检测血清超氧化物歧化酶（ＳＯＤ）和丙二醛（ＭＤＡ）含量，治疗前血清ＳＯＤ、ＭＤＡ含量无显著性差异，分别为８５．２５３±０．０２４ＮＵ／ｍｌ比８５．２８６±０．９８６ＮＵ／ｍｌ，８．４２１±０．０１４μｍｏｌ／Ｌ比７．７２０±０．０２１μｍｏｌ／Ｌ（Ｐ均＞０．０５）。治疗后ＳＯＤ、ＭＤＡ含量有显著性差异，分别为１２２．９３０±０．８?
Objective: To investigate the therapeutic effect of “Nanshen Mixture” on infantile severe pneumonia and congestive heart failure. Methods: A total of 102 children with severe pneumonia and congestive heart failure were randomly divided into treatment group (n = 21) and control group (n = 51). Control group using conventional comprehensive treatment. The treatment group on the basis of comprehensive treatment, plus Salvia injection (birth ~ 3 months of each 2ml, 1 ~ 2 years old, 5ml each) and vitamin C (300 ~ 500mg · kg-1 / d) Drops; and coenzyme Q101 tablets orally, 3 times a day. Results: There were significant differences between the two groups when the symptoms and signs returned to normal. The respiratory rate, heart rate and liver enlargement returned to normal in 1.572 ± 0.101 days and 5.176 ± 0.435 days respectively (P <0.001) and 1.709 ± 0.137 days 4.300 ± 0.396 days (P <0.001) and 1.577 ± 0.156 days vs. 7.500 ± 0.725 days (P <0.001). Serum levels of superoxide dismutase (SOD) and malondialdehyde (MDA) were measured before and after treatment. There was no significant difference in serum SOD and MDA levels before and after treatment (85.253 ± 0.024 NU / ml vs 85, respectively). 286 ± 0.986 NU / ml, 8.421 ± 0.014 μmol / L vs 7.720 ± 0.021 μmol / L (all P> 0.05). After treatment, the contents of SOD and MDA were significantly different (122.930 ± 0.8?