成年Ⅱ型糖尿病中国地鼠肝脏微量元素含量的研究

• 作 者: 蔡炯 刘德惠 孙淑华 苏卫 田金菊 刘素梅
• 机 构: 中国医学科学院中国协和医科大学实验动物研究所
• 出 处: 中国实验动物学杂志
• 发表日期: 1998年01期
• 关键词: Ⅱ型糖尿病 地鼠 雌鼠 原子吸收光度法 后腔静脉 近交系 葡萄糖利用 葡萄糖转运蛋白 标准曲线 免疫功能

应用原子吸收光度法对中国地鼠肝脏微量元素进行分析，结果显示，无论是Ⅱ型糖尿病发病组还是正常对照不发病组的动物，雌性肝脏Ｃｕ的含量都分别比雄性高，在发病组表现得更为显著（分别为Ｐ＜００５和Ｐ＜０００１）；发病组雄性地鼠肝Ｍｇ比同组雌鼠或不发病组雄鼠显著降低（分别为Ｐ＜００１和Ｐ＜００５）；发病组动物肝Ｆｅ含量有增加趋势（２１４ｖｓ１６９μｇ／ｇ）。表明中国地鼠肝组织微量元素的含量和动物Ⅱ型糖尿病的发生、发展有密切联系。

Atomic absorption spectrophotometry was used to analyze the trace elements in liver of hamsters in China. The results showed that the content of Cu in female liver was higher than that in males, both in type Ⅱ diabetes mellitus and non-diseased group (P <005 and P <0001, respectively). The incidence of hepatic Mg in the male rats in the onset group was significantly lower than that in the female rats or non-onset rats (P <001 and P < 0  05); incidence of liver Fe content of animals increased trend (214vs  169μg / g). The results showed that there was a close relationship between the content of trace elements in Chinese hamster liver tissue and the occurrence and development of type II diabetes in animals.