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目的研究氟桂嗪（ＦＮＺ）对实验性脑缺血的保护作用。方法应用Ｆｕｒａ－２荧光比值法测兔大脑中动脉阻断后不同时期血小板胞浆游离［Ｃａ２＋］ｉ浓度变化，观察ＦＮＺ对其变化的影响及对缺血脑水肿的保护作用。结果血小板［Ｃａ２＋］ｉ随缺血时间延长而递增。ＦＮＺ能明显降低脑缺血后的血小板［Ｃａ２＋］ｉ及脑水含量（Ｐ＜０．０１）。结论ＦＮＺ对脑缺血有保护作用
Objective To study the protective effect of flunarizine (FNZ) on experimental cerebral ischemia. Methods Fura-2 fluorescence ratio method was used to measure the change of cytosolic [Ca2 +] i in platelets after different stages of middle cerebral artery occlusion. The effect of FNZ on its changes and the protective effect on ischemic cerebral edema were observed. Results Platelet [Ca2 +] i increased with prolonged ischemia. FNZ significantly reduced platelet [Ca2 +] i and brain water content after cerebral ischemia (P <0.01). Conclusion FNZ has a protective effect on cerebral ischemia