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通过结扎大鼠双侧颈总动脉建立脑缺血再灌注损伤动物模型，采用放射免疫分析技术检测其体内的内皮素（ET）水平，来研究甘糖酯（PGMS）和尼莫地平（NIM）对缺血再灌注损伤大鼠脑实质的影响．实验结果表明，PGMS和NIM都能降低缺血再灌注损伤大鼠血浆及脑组织中ET的含量，保护缺血引起的神经元损伤，为临床治疗脑血管疾病提供了新的思路。
Animal models of cerebral ischemia-reperfusion injury were established by ligation of the bilateral common carotid arteries in rats, and the level of endothelin (ET) was measured by radioimmunoassay to study the effects of PGMS and NIM, Effect of ischemic reperfusion injury on brain parenchyma in rats. The experimental results show that both PGMS and NIM can reduce ET content in plasma and brain tissue of rats with ischemia-reperfusion injury and protect the ischemic neurons from injury, which provides a new idea for clinical treatment of cerebrovascular diseases.