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动物如何保护其粘膜免受环境中致病原的侵袭已引起人们极大的兴趣,并从而提出了粘膜免疫系统的概念,以粘膜上皮与游走性IgA产生细胞的密切关系为其特征.与粘膜相关的淋巴组织表面上皮包含特殊的粘膜细胞.它们可以将大分子颗粒转运给粘膜下的淋巴细胞,使其合成IgA二聚体(IgA_2).但是,为了保护粘膜表面,IgA_2必须以某种方式跨越粘膜或外分泌腺的上皮,释放到外分泌液中.由于上皮细胞间被紧密连接所封闭,这些抗体不能通过简单扩散的方式,而只能通过一种特殊机制被转运.本文就此加以叙述和讨论.分泌成分——一个“献身的受体”
How the animal protects its mucosa from the pathogenic agents in the environment has drawn great interest and led to the concept of the mucosal immune system characterized by the close relationship between mucosal epithelium and migratory IgA-producing cells. Mucosa-associated lymphoid tissue epithelium contains specialized mucosal cells that can transport macromolecular particles to submucosal lymphocytes to synthesize IgA dimer (IgA2), however, IgA2 must be labeled with some kind of In a manner that spans the epithelium of the mucosa or exocrine glands and is released into the exocrine fluid, these antibodies can not be transported by a simple mechanism of diffusion, as the epithelial cells are tightly bound to each other, Discussion. Secretion component - a “devoted recipient”