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动脉粥样硬化(AS)传统上认为是流行病,而不是传染病。但是近20年专家们对病毒感染在AS发病上的可能作用问题重新进行了讨论。早在30年前36ep等就提出肿瘤发生的病毒学理论和病毒一遗传学理论。并认为某些病毒不仅能引起通常的传染病,而且还能引起所谓的非传染病。从70年代初开始Burch等首先指出AS时血管改变与病毒感染有关。以后Fabricant等证明,一种鸟类疱疹病毒—Marek病病毒不仅能引起淋巴增生性改变,而且能引起血管典型的AS性损害;他们还首先明确提出人类AS病因与人类疱疹病毒有关的假说。众所周知人类疱疹病毒有Ⅰ型和Ⅱ型单纯疱疹病毒、风疹病毒、水痘-带状疱疹病毒、巨细胞病毒和EB病毒等。近年研究证实上述假说正确,例如有人报告在患有AS的日本鹌鹑动脉壁细胞中发
Atherosclerosis (AS) is traditionally considered an epidemic rather than an infectious disease. However, nearly 20 years of experts on the possible role of virus infection in the pathogenesis of AS re-discussed. As early as 30 years ago 36ep and so on the tumor theory of virology and viral-genetics theory. And that some viruses not only cause the usual infectious diseases, but also cause the so-called non-communicable diseases. Since the early 1970s, Burch et al. First pointed out that vascular changes are associated with viral infection in AS. Later Fabricant et al. Demonstrated that a herpes virus called Marek could not only cause lymphoproliferative changes but also cause typical AS lesions in blood vessels. They also first clearly put forward the hypothesis that human etiology is related to the human herpesvirus. It is well-known that human herpes viruses include herpes simplex virus type 1 and type 2, rubella virus, varicella-zoster virus, cytomegalovirus and Epstein-Barr virus. Recent studies confirm that the above hypothesis is correct, for example, one reported in Japanese quail artery wall cells with AS hair