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目的探讨卡介苗联合丝裂霉素膀胱灌注对膀胱癌复发及相关细胞因子表达的影响。方法膀胱癌患者56例,术后随机均分为两组:对照组仅给予卡介苗膀胱灌注;试验组采用卡介苗联合丝裂霉素膀胱灌注。比较两组血清细胞因子表达、不良反应、2年复发率及首次复发时间。结果试验组血清IL-2、TNF-α和IFN-γ水平高于对照组(P<0.05),血清IL-10水平低于对照组(P<0.05)。试验组不良反应发生率低于对照组(32.1%vs.82.1%)(P<0.05)。试验组生活质量稳定率高于对照组(82.1%vs.57.1%)(P<0.05)。试验组2年复发率低于对照组(14.3%vs.39.3%)(P<0.05);试验组首次复发时间长于对照组(P<0.05)。结论与单用卡介苗比较,卡介苗联合丝裂霉素膀胱灌注更能有效预防膀胱癌术后复发。
Objective To investigate the effect of intravesical instillation of BCG combined with mitomycin on bladder cancer recurrence and the expression of related cytokines. Methods Fifty-six patients with bladder cancer were randomly divided into two groups: the control group received intravesical instillation of BCG only; the experimental group received intravesical instillation of BCG combined with mitomycin. Serum cytokine expression, adverse reactions, 2-year relapse rate and time to initial relapse were compared between the two groups. Results The serum levels of IL-2, TNF-α and IFN-γ in the experimental group were significantly higher than those in the control group (P <0.05), and the levels of serum IL-10 in the experimental group were lower than those in the control group (P <0.05). The incidence of adverse reactions in the experimental group was lower than that in the control group (32.1% vs 82.2%, P <0.05). The stability of the quality of life of the experimental group was higher than that of the control group (82.1% vs. 57.1%) (P <0.05). The relapse rate in trial group was lower than that in control group (14.3% vs.39.3%, P <0.05). The time to initial relapse in trial group was longer than that in control group (P <0.05). Conclusion Compared with BCG alone, BCG combined with mitomycin C instillation can effectively prevent postoperative recurrence of bladder cancer.