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检测了人乳吞噬细胞对金黄色葡萄球菌、大肠埃希氏菌和铜绿假单胞菌的杀菌效果,并结合扫描电镜和透射电镜观察初乳吞噬细胞与三种细菌相互作用的形态变化。结果表明,母乳吞噬细胞具有相当的吞噬能力、且对大肠埃希氏菌和铜绿假胞菌在2小时内的持续杀菌效果明显优于对金黄色葡萄球菌。观察到母乳吞噬细胞胞浆中存在的大量脂肪空泡在吞噬杀菌过程中与吞噬溶酶体融合的现象,提示母乳吞噬细胞在母乳抗感染保护机制中的独特作用和意义。
The bactericidal effects of human milk phagocytes on Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa were tested. The morphological changes of the interaction between colostrums phagocytes and three kinds of bacteria were observed by scanning electron microscopy and transmission electron microscopy. The results showed that phagocytic cells of human milk have considerable phagocytic capacity, and Escherichia coli and Pseudomonas aeruginosa in two hours of sustained sterilization was significantly better than against Staphylococcus aureus. It is observed that a large number of fat vacuoles existing in cytoplasm of phagocytic cells of human milk swallowed phagolysosomes during phagocytosis, indicating the unique role and significance of breast milk phagocytes in the mechanism of anti-infection of breast milk.