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我们曾推导出迅速达到并维持在稳态水平的三次相继恒速输注法的有关公式。该方法先用快速负荷输注,继以慢速负荷,血药浓度逐步下降,最后用维持输注.使血药浓度持续在期望的稳态水平。本文首先根据家兔静注槐果碱求得的动力学参数,再设计达到期望稳态水平10μg/ml和5μg/ml时,所需的三种相继恒速输注速率和输注时间。结果表明,数学理论模拟血药一时间曲线和实验数据有良好的契合。其超逾浓度较之Wagner提出的二次相继输注法要小。
We have derived the formula for three consecutive constant-rate infusions that quickly reach and remain at steady-state levels. The method begins with a rapid-load infusion followed by a slow load and a gradual decrease in plasma concentration followed by maintenance infusion to maintain the plasma concentration at the desired steady-state level. Based on the kinetic parameters obtained from intravenous administration of sophocarpine in rabbits, we designed three constant-rate infusion rates and infusion times required to reach steady-state levels of 10 μg / ml and 5 μg / ml. The results show that the mathematical theory of simulated blood drug a curve of time and experimental data have a good fit. The excess concentration is smaller than that of Wagner’s second consecutive infusion.