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目的：为了探讨同安县原发性肝癌（PHC）高发的主要危险因素。方法：应用流行病学调查研究的方法，开展了1：2配对的PHC危险因素病例一对照、ELISA法的高危人群筛检、HBV＄染与PHC关系的前瞻性研究。结果;HBsAg携带率病例组高于对照组，抗一HBs阳性率病例组低于对照组;HBsAg、AFP阳性率男性高于女性，抗-HBs阳性率男性低于女性;HBsAg（十）者的肝癌发生率高于HBsAg（-）者，HBsAg（十）、HBeAg（＋）者的PHC发生率低于HBsAg（十）、AFP（十）者的PHC发生率，与HBsAg（＋）者无显著性差异。结论;在同安，HBsAg（＋）与PHC的发生有病因学的相关关系，HBsAg携带者的AFP阳性状态更增加了发生PHC的危险性。
Objective: To investigate the main risk factors for high incidence of primary liver cancer (PHC) in Tongan County. METHODS: Using epidemiological investigation methods, a 1:2 paired PHC risk factor case-control study, ELISA screening for high-risk populations, and a prospective study of the relationship between HBV infection and PHC were performed. Results; HBsAg carrier rate was higher in the case group than in the control group, and the anti-HBs positive rate was lower in the case group than in the control group; HBsAg, AFP positive rate was higher in men than in women, and anti-HBs positive rate was lower in men than in women; HBsAg (10) in those The incidence of liver cancer was higher than that of HBsAg(-). The incidence of PHC in HBsAg(10) and HBeAg(+) was lower than that in HBsAg(10) and AFP(10). There was no significant difference between HBsAg(+) and HBsAg(+). Sexual differences. Conclusion: In Tongan, HBsAg(+) and PHC have associated etiology, and the AFP positive status of HBsAg carriers increases the risk of PHC.