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目的探究颅脑损伤伴低血钠症病人血清中Ang-Ⅱ、ADH、ANP含量与血中Na+相关性。方法分析2013年1月~2014年12月81例在我院进行治疗的颅脑损伤患者的临床资料,将血Na+含量<135mmol/l患者设为观察组,血Na+含量处于正常范围内(135~150mmol/l)的患者作为对照组。比较不同血钠水平的颅脑损伤患者不同时期血清中Ang-Ⅱ、ADH、ANP含量变化,观察血清中AT-Ⅱ、ADH、ANP含量与血中Na+相关性。结果观察组患者伤后血清中Ang-Ⅱ、ADH、ANP含量明显高于对照组,差异均具有统计学意义(P<0.05)。两组研究对象组内比较发现,随着时间发展,两组研究对象血清中Ang-Ⅱ、ANP含量明显升高,血浆中ADH含量显著下降,组内比较差异均具有统计学意义(P<0.05);观察组患者血清Na+含量明显低于对照组,差异具有统计学意义(t=15.71,P<0.001);观察组患者7d后血清中Ang-Ⅱ(r=-0.740,P<0.001)、ADH(r=-0.678,P<0.001)、ANP(r=-0.653,P<0.001)与血Na+呈现显著负相关关系。结论颅脑损伤伴低钠血症患者血清中Ang-Ⅱ、ADH、ANP与血Na+呈现负相关关系。
Objective To investigate the correlation between Ang-Ⅱ, ADH and ANP in serum and Na + in blood in patients with craniocerebral injury and hyponatremia. Methods Clinical data of 81 patients with brain injury treated in our hospital from January 2013 to December 2014 were analyzed. The patients with blood Na + <135mmol / l were selected as the observation group and the blood Na + level was in the normal range (135 ~ 150mmol / l) as control group. The levels of Ang-Ⅱ, ADH and ANP in serum of patients with craniocerebral injury at different levels of serum sodium were compared. The levels of AT-Ⅱ, ADH and ANP in serum and the levels of Na + in blood were observed. Results The contents of Ang-Ⅱ, ADH and ANP in the observation group were significantly higher than those in the control group, the differences were statistically significant (P <0.05). Compared with the two groups, it was found that with the development of time, the levels of Ang-Ⅱ and ANP in the serum of the two groups were significantly increased and the levels of ADH in the plasma were significantly decreased (P <0.05 ). The level of serum Na + in the observation group was significantly lower than that in the control group (t = 15.71, P <0.001). The level of serum Ang-Ⅱ (r = -0.740, ADH (r = -0.678, P <0.001), ANP (r = -0.653, P <0.001) had a significant negative correlation with blood Na +. Conclusion Serum levels of Ang-Ⅱ, ADH and ANP in patients with craniocerebral injury and hyponatremia have a negative correlation with blood Na + level.