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目的探究肾病患者多种骨代谢生化指标的变化情况。方法选取郑州颐和医院2013年10月至2015年10月肾病患者53例设置为观察组,再选取同期体检的健康人50例设置为对照组。比较两组血清钙(血Ca)、磷(P)、甲状旁腺素(PTH)、骨钙素(BGP)、25-羟维生素D3(25-OH-D3)、I型胶原吡啶交联C终端肽(CTx)、骨密度(BMD)、尿钙/尿肌酐(UCa/Cr)、骨钙素(OCN)水平差异及骨质疏松发生率。结果观察组血清Ca、P水平较健康对照组显著较低(P<0.05);观察组血清BGP、25-OH-D3、CTx、BMD、UCa/Cr、OCN水平较健康对照组显著较高(P<0.05);观察组患者骨质疏松发生率为28.30%,高于健康对照组(P<0.05);观察组和健康对照组骨密度正常率分别为35.85%、68.00%,差异有统计学意义(P<0.05)。结论肾病患者存在骨代谢异常症状,骨质的形成和吸收间的平衡关系受到破坏,骨代谢指标能敏感的反映出肾病患者的骨代谢变化,能作为观察肾病患者骨质疏松发生的重要指标。
Objective To investigate the changes of multiple biochemical markers of bone metabolism in patients with nephropathy. Methods Fifty-three patients with kidney disease in Zhengzhou Yihe Hospital from October 2013 to October 2015 were selected as the observation group, and 50 healthy subjects were selected as the control group. The levels of serum Ca, P, PTH, BGP, 25-OH-D3, collagen I-C cross-linked C CTx, BMD, UCa / Cr, OCN and the incidence of osteoporosis. Results Serum levels of Ca and P in observation group were significantly lower than those in healthy control group (P <0.05). Serum levels of BGP, 25-OH-D3, CTx, BMD, UCa / Cr and OCN in observation group were significantly higher than those in healthy control group P <0.05). The incidence of osteoporosis in observation group was 28.30%, which was higher than that in healthy control group (P <0.05). The normal rates of bone mineral density in observation group and healthy control group were 35.85% and 68.00% Significance (P <0.05). Conclusions There are abnormalities of bone metabolism in patients with nephropathy, and the balance between the formation and absorption of bone is destroyed. The indexes of bone metabolism can reflect the changes of bone metabolism in patients with nephropathy and can be used as an important index to observe the occurrence of osteoporosis in patients with nephropathy.