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目的 :比较黄芩甙与甘露醇、地塞米松对感染性脑水肿的治疗作用 ,为脑水肿的临床治疗探讨新的方法。方法 :应用感染性脑水肿模型 ,将 40只SD大鼠随机分为感染性脑水肿 (BE)组、甘露醇治疗 (MAN)组、地塞米松治疗 (DXM)组、黄芩甙治疗 (BC)组及生理盐水对照 (NS)组 ,观察脑组织含水量、干脑组织钠、钾离子含量、伊文思兰 (EB)含量、脑组织病理形态学变化。结果 :大鼠脑组织含水量、EB含量、钠离子含量BE组高于其他组 (P <0 .0 1 )。MAN ,DXM ,EC三组间脑组织含水量、钠离子含量差异无显著性 (P >0 .0 5)。BC组的EB含量高于MAN ,DXM组 (P<0 .0 1 )。BE组钾离子含量低于生理盐水组和BC组 (P <0 .0 1 ) ;与MAN ,DXM组相近 (P >0 .0 5)。MAN ,DXM ,BC组脑组织水肿程度较BE组减轻 ,仅见少量的血管周围间隙增宽 ,偶有神经细胞核固缩 ,DXM组无神经细胞空泡样变性。结论 :黄芩甙与甘露醇、地塞米松对于感染性脑水肿均有类似的治疗效果 ,它们的作用强度相近似 ,但作用机制不尽相同
Objective: To compare the therapeutic effects of baicalin, mannitol and dexamethasone on infectious brain edema, and to explore a new method for the clinical treatment of cerebral edema. METHODS: Forty Sprague-Dawley rats were randomly divided into 2 groups: BE, MAN, DXM, BC, (NS) group, and the water content of brain tissue, the content of sodium and potassium in brain tissue, the content of Evans blue (EB) and the histopathological changes of brain tissue were observed. Results: The brain water content, EB content and sodium ion content of BE group were higher than other groups (P <0.01). There was no significant difference in the contents of water and sodium among the three groups of MAN, DXM and EC (P> 0.05). The content of EB in BC group was higher than that in MAN group and DXM group (P <0.01). The potassium level in BE group was lower than that in saline group and BC group (P <0.01), similar to MAN and DXM group (P> 0.05). The brain edema in MAN, DXM and BC groups was less than that in BE group, with only a small amount of perivascular space widened, with occasional nerve cell nucleus pyknosis and no vacuolar degeneration of nerve cells in DXM group. Conclusion: Baicalin and mannitol, dexamethasone have similar therapeutic effect on infectious brain edema, their intensity is similar, but the mechanism of action is not the same