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多囊卵巢综合征(PCOS)患者机体内分泌及代谢异常对排卵周期、卵泡质量等具有不利影响,常因自发排卵障碍而接受辅助生殖治疗。PCOS患者卵巢无优势卵泡且缺乏自我调节,促排卵治疗中易发生卵巢反应性过高或低下。卵巢反应性过高在严重时可发生卵巢过度刺激综合征(OHSS),不仅影响辅助生殖治疗的顺利进行,甚至威胁患者生命。在体外受精-胚胎移植(IVF-ET)治疗过程中,多项研究分析发生卵巢反应异常的相关危险因素,例如雌二醇、抗苗勒氏管激素及获卵数等,但如何综合多项指标根据PCOS患者个体情况预测卵巢反应性并防止OHSS的发生、提高受孕概率仍需要进一步临床实验研究。
Polycystic ovary syndrome (PCOS) patients with abnormal endocrine and metabolic disorders on ovulation cycle, follicular quality and other adverse effects, often due to spontaneous ovulation disorders and assisted reproductive therapy. PCOS patients with no dominant ovarian follicles and lack of self-regulation, ovulation induction ovarian reaction prone to high or low. Ovarian hyperstimulation may occur in severe ovarian hyperstimulation syndrome (OHSS), not only affect the smooth progress of assisted reproductive therapy, and even life-threatening patients. In the course of in vitro fertilization-embryo transfer (IVF-ET), a number of studies have analyzed related risk factors for ovarian response abnormalities such as estradiol, anti-mullerian hormone and number of oocytes retrieved. However, Indicators Predict ovarian response and prevent the occurrence of OHSS according to the individual condition of patients with PCOS. To improve the probability of conception still need further clinical experimental research.