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传统观点认为 ,血脑屏障 (BBB)在正常状态下限制免疫活性细胞和肽类大分子入脑 ,使脑成为稳定的免疫特免区。但现代研究发现 ,BBB并不是一个固定不变的脑和免疫系统间的屏障 ,其通透性可因多种因素改变 ,从而为免疫系统与中枢神经系统 (CNS)之间的通讯提供了可能的途径 ;组成BBB的各个成分也表达粘附分子及其它细胞表面抗原 ,或产生细胞因子而参与对入脑的免疫活性细胞的限制、抗原识别和提呈 ,在CNS免疫调节中发挥着复杂而重要的作用
The traditional view is that the blood-brain barrier (BBB) limits the activation of immunocompetent cells and peptide macromolecules into the brain under normal conditions, making the brain a stable immunocompetent region. However, modern studies have found that BBB is not a static barrier between the brain and the immune system, and its permeability can be altered by a variety of factors that make it possible for the immune system to communicate with the central nervous system (CNS) ; The components that make up the BBB also express adhesion molecules and other cell surface antigens or produce cytokines that participate in the restriction of the immunocompetent cells into the brain, antigen recognition and presentation, and play a complex role in CNS immunomodulation Important role