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目的 :观察雷公藤含药血清对肾小球系膜细胞 (MC)增殖的影响 ,并初步探讨其作用机制。方法 :大鼠肾小球 MC体外培养技术及血清药理学方法。结果 :雷公藤血清能显著抑制脂多糖 (L PS)刺激的 MC增殖 ,并可降低 L PS刺激的 MC培养上清液中 NO、NOS(一氧化氮合酶 )的含量。结论 :雷公藤抑制 MC增殖的作用机制之一可能是通过抑制 NO、NOS分泌
Objective: To observe the effects of serum containing Tripterygium wilfordii on the proliferation of glomerular mesangial cells (MC), and to explore its mechanism of action. Methods: In vitro culture of rat glomerular MC and serum pharmacology. RESULTS: Tripterygium wilfordii could significantly inhibit the proliferation of LPS-stimulated MC and reduce the content of NO and NOS (nitric oxide synthase) in MC culture supernatant stimulated by LPS. Conclusion : One of the mechanisms of Tripterygium wilfordii inhibiting MC proliferation may be through inhibiting the secretion of NO and NOS.