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本文采用随机双盲对照法以左旋吡喹酮(Levopraziquantel,L-P)与吡喹酮(Praziquantel,P)一剂治疗粪检阳性的日本血吸虫病278例(139对配对),其中慢性早期(慢血)268例,晚期(晚血)10例。L-P组剂量为20mg/kg,P组为40mg/kg,一次顿服,治后4～6个月,L-P组粪检阴转率分别为94.85％、96.27％;P组粪检阴转率分别为97.06％、94.03％,(P>0.05),L-P20mg/kg治疗轻、中度感染是可行的,疗效与P40mg/kg相仿。L-P剂量小、毒副反应轻、安全、简便、有利于大规模治疗的开展。
In this study, 278 cases (139 paired) of schistosomiasis japonica schistosomiasis were treated with Levopraziquantel (LP) and Praziquantel (P) in a randomized, double-blind, controlled trial. Chronic early ) 268 cases, late (late blood) in 10 cases. LP group dose of 20mg / kg, P group 40mg / kg, a dose of Dayton, 4 to 6 months after treatment, LP group fecal septal negative conversion rates were 94.85%, 96.27% 97.06%, 94.03%, respectively (P> 0.05). L-P 20mg / kg was effective in the treatment of mild and moderate infections with similar efficacy as P40mg / kg. L-P dose is small, toxic side effects, safe, simple, conducive to large-scale treatment.