论文部分内容阅读
目的:探讨受体相互作用蛋白1在结肠癌中的表达及其与临床病理特征的关系。方法:使用免疫组织化学检测97例结肠癌组织及癌旁组织中受体相互作用蛋白1的表达情况,结合临床病理资料进行统计学分析。结果:97例结肠癌患者中,癌组织中受体相互作用蛋白1阳性表达的有41例(42.3%),癌旁组织中阳性表达的有78例(80.4%),差异有统计学意义(P<0.05)。结肠癌组织中受体相互作用蛋白1的表达与年龄、性别无关,与患者临床分期、病理分级、淋巴结转移相关。结论:结肠癌中受体相互作用蛋白1表达降低可能是判断结肠癌患者预后一个潜在参考指标。
Objective: To investigate the expression of receptor-interacting protein 1 in colon cancer and its relationship with clinicopathological features. Methods: Immunohistochemistry was used to detect the expression of receptor-interacting protein-1 in 97 cases of colorectal cancer tissues and adjacent tissues. The clinical and pathological data were used for statistical analysis. Results: Of the 97 colon cancer patients, 41 (42.3%) were positive for receptor-interacting protein 1 in cancerous tissues and 78 (80.4%) were positive for paracancerous tissues, the difference was statistically significant ( P <0.05). The expression of receptor-interacting protein 1 in colon cancer tissues was not related to age and gender, and was correlated with clinical stage, pathological grade and lymph node metastasis. CONCLUSIONS: The decreased expression of receptor-interacting protein 1 in colon cancer may be a potential reference for the prognosis of patients with colon cancer.