论文部分内容阅读
目的:为新型冠状病毒疫苗加速研发提供参考。方法:依托科睿唯安Cortellis数据库，通过检索全球冠状病毒疫苗的研发状态、技术路线、临床试验及专利等数据，分析目前冠状病毒疫苗的整体研发态势和技术布局。结果:全球在研87个冠状病毒疫苗，主要针对8种适应症。重组病毒载体疫苗、蛋白亚单位疫苗以及核酸疫苗等技术路线运用较多。临床试验较少仅38个，多数处于临床试验早期。专利类型主要集中在高分子产品、生物技术治疗、处方、药物研发和筛选以及工艺等方面。结论:通过全面分析冠状病毒疫苗研发态势和技术布局，能够从多方面为新型冠状病毒疫苗的研发工作提供参考及助力。“,”Objective:To provide references for accelerated development of novel coronavirus vaccines.Methods:Based on the Cortellis database, we analyzed and summarized the current research and development situation and technology layout of global coronavirus vaccines by searching the development status, technical route, clinical trials, and patents of global coronavirus vaccines in this article.Results:There are eighty-seven kinds of coronavirus vaccines under development in the world, mainly for 8 indications; among them, recombinant viral vector vaccines, protein subunit vaccines, and nucleic acid vaccines are widely used. There are 38 clinical trials, and most of them are at early-phase. The types of patents are mainly macromolecule product, biotechnological therapy, formulation, drug discovery and screening, and process.Conclusions:This comprehensive analysis of the development situation and technical layout of coronavirus vaccines will provide references and assistance for the development of new coronavirus vaccines.