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为了解病毒性心肌炎患儿急性期血清白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)的含量改变及其与乳酸脱氢酶同工酶1(LDH_1)的关系,初步探讨两者在病毒性心肌炎发病中的作用,分别采用ELISA法和酶法检测72例病毒性心肌炎患儿的血清IL-6、TNF-α和LDH_1含量,结果病毒性心肌炎组血清IL-6、TNF-α、LDH_1含量均明显高于正常对照组(P<0.01)。IL-6水平与LDH_1呈负相关(r=-0.352,P<0.01),TNF-α水平与LDH_1呈正相关(r=0.427,P<0.01),结论表明IL-6、TNF-α参与了病毒性心肌炎的发病过程,TNF-α加重心肌损伤,IL-6有感染防御性作用,两者起不同作用,其检测可作为临床判断病毒性心肌炎患儿病情程度的指标。
To investigate the changes of serum interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α) and their relationship with lactate dehydrogenase isoenzyme 1 (LDH-1) in children with viral myocarditis Serum levels of IL-6, TNF-α and LDH_1 in 72 children with viral myocarditis were measured by enzyme-linked immunosorbent assay (ELISA) and enzymatic method respectively. Results Serum IL-6 , TNF-α, LDH_1 were significantly higher than the normal control group (P <0.01). The level of IL-6 was negatively correlated with LDH 1 (r = -0.352, P <0.01). The level of TNF-α was positively correlated with LDH 1 (r = 0.427, P <0.01) The pathogenesis of myocarditis, TNF-α aggravating myocardial injury, IL-6 have a defensive role in infection, both play different roles, and its detection can be used as an indicator of clinical severity of children with viral myocarditis.