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目的探讨凝血功能与脓毒症患者病情严重程度与临床预后之间的关系。方法收集2012年1月至2014年6月,郑州市儿童医院ICU收治的脓毒症患者72例,根据APACHEⅡ评分分为低分组、中分组和高分组;根据临床预后分为存活组与死亡组,比较各组的凝血功能指标。结果不同APACHEⅡ评分组的PT、PLT及AT-Ⅲ差异显著(P<0.05);死亡组的PT较存活组显著延长,AT-Ⅲ以及PLT均较存活组显著降低(P<0.05);相关性分析显示,PT、AT-Ⅲ、PLT与APACHEⅡ评分呈显著相关性(P<0.05)。结论脓毒症患者的病情越严重,凝血功能障碍程度越严重,临床预后越差,早期发现并采取有效措施改善凝血功能障碍有利于改善临床预后。
Objective To investigate the relationship between the severity of patients with coagulation and sepsis and clinical prognosis. Methods Seventy-two patients with sepsis admitted to ICU of Zhengzhou Children’s Hospital from January 2012 to June 2014 were divided into low-grade group, middle-grade group and high-grade group according to APACHEⅡscore. According to clinical prognosis, they were divided into survival group and death group , Compare the coagulation function index of each group. Results There were significant differences in PT, PLT and AT-Ⅲ between different APACHEⅡscore groups (P <0.05). The PT in the death group was significantly longer than that in the survivor group, while AT-Ⅲ and PLT were significantly lower than those in the survivor group (P <0.05) Analysis showed that PT, AT-Ⅲ, PLT and APACHE Ⅱ scores were significantly correlated (P <0.05). Conclusions The more serious the condition of sepsis patients, the more severe coagulation dysfunction and the worse clinical prognosis. Early detection and effective measures to improve coagulation dysfunction are helpful to improve clinical prognosis.