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目的研究单阳家庭阴性配偶人体免疫缺陷病毒(human immunodeficiency virus,HIV)感染影响,同时对高效抗反转录病毒在预防单阳家庭配偶间HIV性传播的作用和效果进行评估。方法在2008—2016年使用非概率法选取开封市HIV单阳家庭的社会人口进行高效抗逆转录病毒治疗(highly active antiretroviral therapy,HAART)在配偶间HIV性传播综合干预,记录家庭单位中阴性配偶的HIV抗体阳转变化,完成对该地区高效抗逆转录病毒在单阳家庭内HIV性传播干预的回顾性分析和夫妻间HIV传播关系的梳理,计数资料比较采用χ~2检验,P<0.05为差异有统计学意义。结果选取开封市2008—2010年的288对、2011—2013年的345对和2014—2016年的382对HIV单阳家庭队列进行研究,2008—2010年出现了12.15%家庭阴性配偶HIV抗体阳转变化,2011—2013年出现4.06%阳转,2014—2016年出现1.31%阳转,对比差异有统计学意义(P<0.05)。结论开封市单阳家庭阴性配偶HIV抗体阳转率稳定在较低水平,且在本研究的随访时间中未发现HAART的预防作用随治疗时间延长而消失。
Objective To study the influence of HIV infection in single-negative family spouse with HIV and to evaluate the effect and effectiveness of anti-retrovirus in preventing HIV transmission among spouses of single-yang families. Methods In 2008-2016, the non-probable method was used to select the highly active antiretroviral therapy (HAART) in the social population of HIV single-positive families in Kaifeng. In inter-spouse HIV transmission comprehensive intervention, the negative spouse HIV antibody positive changes in the region to complete the retrospective analysis of HIV transmission in the single-positive families in the region and the combing of the relationship between husband and wife HIV transmission, count data were compared using the χ ~ 2 test, P <0.05 For the difference was statistically significant. Results A total of 288 pairs from 2008 to 2010 in Kaifeng City, 345 pairs in 2011-2013 and 382 pairs of HIV single positive family cohorts in 2014-2016 were selected. In 2008-2010, 12.15% , With a positive rotation of 4.06% in 2011-2013 and a positive rotation of 1.31% in 2014-2016. The difference was statistically significant (P <0.05). Conclusion The positive rate of HIV antibody in single negative family spouse of Kaifeng was stable at a low level. The preventive effect of HAART was not found to disappear with the prolongation of treatment time during the follow-up period of this study.