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目的 :为研究降钙素基因相关肽在先兆子痫病生机制中的作用。方法 :本文采用放射免疫测定法测定了 2 1例健康未妊娠妇女 (未妊娠组 ) ,2 5例正常妊娠妇女 (妊娠组 )及 2 5例先兆子痫患者 (先兆子痫组 )血浆降钙素基因相关肽水平 ,同时测定了妊娠组与先兆子痫组胎盘组织及胎儿血浆降钙素基因相关肽水平。结果 :在妊娠组与先兆子痫组间 ,母体与胎儿血浆中以及胎盘组织中降钙素基因相关肽含量均无明显变化 (P >0 .0 5 ) ,但母体与胎儿血浆含量具有明显相关性。结论 :降钙素基因相关肽在先兆子痫的病生机制上并不起重要作用
Objective: To investigate the role of calcitonin gene-related peptide in pathogenesis of preeclampsia. Methods: Radioimmunoassay was used to determine the plasma levels of plasma calcium in 21 healthy pregnant women (non-pregnant women), 25 normal pregnant women (pregnant women) and 25 preeclampsia patients (preeclampsia) The level of calcitonin gene-related peptide in placental tissue and fetus in pregnant women and pre-eclampsia group were also determined. Results: The levels of calcitonin gene-related peptide in maternal and fetal plasma as well as in placenta between pregnancy group and preeclampsia group had no significant changes (P> 0.05), but the plasma levels of maternal and fetus were significantly correlated Sex. CONCLUSION: Calcitonin gene-related peptide does not play an important role in the pathogenesis of preeclampsia