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一些报道认为大剂量的维生素 C(下称 VC),对于感冒可以减轻症状,缩短病程。但大量 VC 在人体的吸收是一个复杂的过程,剂型、剂量及胃肠道的生理状况均可影响它的吸收速度和程度。本文对4名健康志愿者进行了4种剂型的生物利用度测定。这4种剂型是:粉剂、片剂、咀嚼片、缓释胶囊。口服剂量均为1g,并以静注做对照。尿液中的回收率,静注为84.7±2.5;粉剂、片剂及咀嚼片分别为32.1±16.6,29.8±17.6和30.4±19.9。缓释胶囊为14.2±7.2。静注后4名受试者之间的尿液回收率差异较小,而几种口服剂型的个体差异均较大。这说明 VC 在人体的吸收存在着一个特殊的转运过程,这一特定的转运过程只发生在胃肠道的某一位置,这
Some reports suggest that high doses of vitamin C (hereinafter referred to as VC) can relieve symptoms and shorten the course of the disease for the common cold. However, a large number of VC absorption in the body is a complex process, dosage form, the physiological status of the gastrointestinal tract can affect its speed and extent of absorption. Four healthy volunteers were tested for their bioavailability in four different dosage forms. These four dosage forms are: powder, tablet, chewable tablets, slow release capsules. Oral doses were 1g, and intravenous control. Urine recovery, intravenous injection of 84.7 ± 2.5; powder, tablet and chewable tablets were 32.1 ± 16.6, 29.8 ± 17.6 and 30.4 ± 19.9. Sustained-release capsules were 14.2 ± 7.2. There was a small difference in urinary recovery between the 4 subjects after intravenous injection, whereas individual differences in several oral dosage forms were greater. This shows that the absorption of VC in the human body there is a special transport process, this particular transport process occurs only in the gastrointestinal tract of a place, which