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雌性激素具有抗动脉粥样硬化作用 ,但具有明显的副作用 ,近年争议尤甚。我们发现了一种新的植物雌激素α玉米赤霉醇 ,并于 1996年首次引进医学研究领域。为了探讨α玉米赤霉醇抗动脉粥样硬化与改善脂质代谢的作用并与雌激素进行比较 ,将 6 0只新西兰成熟未孕兔分成 7组 :正常对照组 6只 ,普通饲料喂养 ;假手术组 8只 ,作假手术 ;高脂对照组 10只 ,小剂量玉米赤霉醇组 8只 ,中剂量玉米赤霉醇组 10只 ,大剂量玉米赤霉醇组 8只 ,雌二醇组 10只 ;上述各组除正常对照组和假手术组外 ,均作了卵巢摘除术 ;除正常对照组外均喂高脂饲料 12周。在实验开始时和第 4、8、12周时分别测定血清总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、载脂蛋白Al和B。实验结束时处死动物 ,取主动脉标本 ,油红O染色 ,肉眼观察并用扫描仪测定兔主动脉内膜脂质斑块沉积面积与主动脉内膜总面积之比 ,另取小块主动脉常规切片作病理观察。结果发现 ,主动脉内膜脂质斑块与内膜总面积之比 ,正常对照组为 0 .0 2± 0 .0 0 3;假手术组为 0 .42± 0 .15 ;高脂对照组为 0 .6 7± 0 .2 3;小剂量玉米赤霉醇组为 0 .6 1± 0 .13;中剂量玉米赤霉醇组为 0 .10± 0 .0 6 ;大剂量玉米赤霉醇组为 0 .32± 0 .10 ;雌二醇组为 0 .12± 0
Estrogen has anti-atherosclerotic effects, but has obvious side effects, especially controversial in recent years. We found a new phytoestrogen alpha zearalenol, which was first introduced into medical research in 1996. In order to investigate the anti-atherosclerosis effect of α-zearalenol on lipid metabolism and to compare with estrogen, 60 mature immature rabbits in New Zealand were divided into 7 groups: 6 in normal control group, normal feeding group, The rats in the operation group were given sham operation. There were 10 rats in the high-fat control group, 8 in the low-dose zearalenol group, 10 in the medium-dose zearalenol group, 8 in the high-dose zearalenol group and 10 in the estradiol group Except the normal control group and sham operation group, ovariectomy was performed in all the above groups; except for the normal control group, high-fat diet was fed for 12 weeks. Serum total cholesterol, triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol, apolipoproteins Al and B were measured at the beginning of the experiment and at the 4th, 8th and 12th week respectively. The animals were sacrificed at the end of the experiment, the aorta specimens were taken and stained with Oil Red O. The ratio of the deposition area of the intima of the rabbit aorta to the total area of the aorta intima was measured with a naked eye. Another small aorta routine Slices for pathological observation. The results showed that the ratio of the aortic intima plaque to the total intima area in the normal control group was 0.002 ± 0.030; in the sham-operated group was 0.42 ± 0.15; in the high-fat control group Was 0.67 ± 0.23; low dose of zearalenol group was 0.61 ± 0.13; medium dose of zearalenol group was 0.10 ± 0. 06; high dose of zeara Alcohol group was 0.32 ± 0.10; estradiol group was 0.12 ± 0