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目的探讨阿托伐他汀对急性心肌梗死患者高敏C反应蛋白(hs-CRP)和血脂异常的影响。方法选择急性心肌梗死患者106例,随机分成两组;常规组52例给予常规治疗,他汀组54例在常规治疗基础上加用阿托伐他汀20mg每晚1次顿服;分别在发病24h内及14d后抽血检测血清hs-CRP及血脂水平,比较两组间差异。结果入院初两组患者血清hs-CRP、TC、LDL-C、HDL-C和TG水平比较差异无统计学意义(P>0.05);治疗14d后,他汀组血清hs-CRP水平明显低于常规组(P<0.001);而血脂水平比较差异无统计学意义(P>0.05)。结论阿托伐他汀短期即可发挥抗炎作用,且此作用不依赖于调脂作用。
Objective To investigate the effect of atorvastatin on high sensitivity C-reactive protein (hs-CRP) and dyslipidemia in patients with acute myocardial infarction. Methods A total of 106 patients with acute myocardial infarction (AMI) were randomly divided into two groups. Conventional treatment was given in 52 patients. 54 patients in the statin group were treated with atorvastatin 20mg once daily at night on a routine basis. And 14d after blood test serum hs-CRP and blood lipid levels were compared between the two groups. Results There was no significant difference in serum hs-CRP, TC, LDL-C, HDL-C and TG levels between the two groups (P> 0.05). After 14 days of treatment, serum hs-CRP levels in statins group were significantly lower than those in routine (P <0.001), while there was no significant difference in the level of serum lipids (P> 0.05). Conclusion Atorvastatin can exert anti-inflammatory effect in a short time, and this effect does not depend on lipid-lowering effect.