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目的：探讨骨髓纤维化的程度对小儿急性白血病预后的影响。方法：在治疗前作骨髓活检。结果：76例中63例有不同程度的纤维化，在有治疗条件下，有骨髓纤维化者较无纤维化者死亡率高，比较严重纤维化与轻中度纤维化之间死亡率亦有同样发现。经统计学处理，两者均有统计学意义。结论：骨髓纤维化对急性白血病患儿的预后有明显的影响，且预后随纤维化程度的加重而严重。
Objective: To investigate the effect of the degree of myelofibrosis on the prognosis of children with acute leukemia. Methods: Bone marrow biopsy was performed before treatment. Results: Of the 76 cases, 63 cases had different degree of fibrosis. Under the condition of treatment, the mortality rate of patients with myelofibrosis was higher than that without fibrosis, and the mortality rate was more serious between fibrosis and mild-to-moderate fibrosis Also found. After statistical analysis, both were statistically significant. Conclusion: Myelofibrosis has a significant effect on the prognosis of children with acute leukemia, and the prognosis is aggravated with the severity of fibrosis.