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本文用抗磷酸激活的谷氨酰胺酶的单克隆抗体和抗代谢型谷氨酸受体五种亚型（1，1α，2／3，5）的4种抗体，研究了三叉神经脊束核尾侧亚核和三叉神经半月节内磷酸激活的谷氨酰胺酶样免疫反应阳性神经元和终末以及五种代谢型谷氨酸受体的分布，同时结合HRP逆标技术对三叉神经脊束核尾侧亚核内磷酸激活的谷氨酰胺酶样阳性终末的来源进行了观察．发现磷酸激活的谷氨酰胺酶样阳性胞体和终末主要集中在三叉尾侧亚核的Ⅰ、Ⅱ层；半月节内仅有它的阳性胞体。半月节内HRP逆标神经元中呈磷酸激活的谷氨酰胺酶样阳性者占71．4％，这些双重反应阳性神经元占半月节内磷酸激活的谷氨酰胺酶样阳性神经元的33．2％．五种代谢型谷氨酸受体亚型中，只有5型密集地分布于三叉尾侧亚核的Ⅰ、Ⅱ层。以上结果说明：（1）三叉尾侧亚核内的磷酸激活的谷氨酰胺酶样阳性终末主要位于其浅层，它们主要来源于三叉神经的初级传入；（2）三叉尾侧亚核的代谢型谷氨酸受体五种亚型中，只有5型可能参与西口部伤害性刺激信息的传递；（3）三叉尾侧亚核内磷酸激活的谷氨酰胺酶样阳性终末的分布与代谢型谷氨酸受体5型的分布互相匹配。
In this paper, the anti-phosphate-activated glutaminase monoclonal antibody and anti-metabotropic glutamate receptors five subtypes (1,1α, 2 / 3,5) of the four antibodies, the trigeminal nerve bundle nucleus Tail subunit and trigeminal nerve in the meniscus phosphoglycerate-like glutamase-like immunoreactive positive neurons and terminals and the distribution of five metabotropic glutamate receptors, combined with HRP reverse-labeled technique on the trigeminal nerve bundle The origin of phosphoglycan-positive glutaminase-like positive terminals in nucleus caudalis was observed. Found that phosphorylated glutamase-like positive soma and terminal mainly in the trigeminal side of the sub-nucleus Ⅰ, Ⅱ layer; half of the moon only its positive cell body. 71.4% of the phosphoglycan-positive glutamase-like positive neurons in the HRP retrograde neurons in the semilunar period accounted for 33% of the phosphoramidate-positive glutamase-like neurons in the semilunar section. 2%. Of the five metabotropic glutamate receptor subtypes, only 5 are densely distributed in the Ⅰ and Ⅱ layers of the trigeminal caudal subnucleus. The above results indicate that: (1) Phospho-activated glutaminase-like terminals in the trigeminal caudal subfractions are mainly located in the superficial layer, they mainly originate from the primary afferent of the trigeminal nerve; (2) Of the five subtypes of metabotropic glutamate receptors, only type 5 may participate in the transmission of noxious stimulation information in the mouth of the mouth. (3) Distribution of phosphoglycan-activated glutaminase-like positive terminals in the trigeminal caudal nucleus And metabotropic glutamate receptor type 5 distribution match each other.