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目的探讨健康老年人和老年ＣＯＰＤ患者肺弥散功能差异和临床应用价值。方法用美国６２００ＡｕｔｏｂｏｘＤＬ型体积描记仪分别测定９７例健康老年人和１１７例ＣＯＰＤ患者的肺弥散功能。结果慢支组与健康组比较肺一氧化碳弥散量（ＤＬＣＯ）差异非常显著（Ｐ＜０．０１）。轻、中、重度肺气肿组与健康组比较ＤＬＣＯ、弥散量／肺泡容积比值（ＤＬＣＯ／ＶＡ）、转送系数（Ｋｃｏ）、弥散时间常数（ＣＯＴ．Ｃ．）相差非常显著（Ｐ＜０．０１）。结论老年人患有慢性呼吸道病变时，肺弥散功能测定是一项较为敏感的指标，常在其他肺功能检查出现异常之前就已有变化。
Objective To investigate the difference of pulmonary diffuse function and clinical value between healthy elderly and elderly COPD patients. Methods Pulmonary diffuse function was measured in 97 healthy elderly and 117 COPD patients using the American 6200 Autobox DL plethysmograph. Results The differences of diffusing capacity of carbon monoxide in chronic bronchitis group and healthy group were significant (P <0.01). The differences of DLCO, DLCO / VA, Kco, and COT.C between the mild, moderate and severe emphysema groups were significant (P <0. 01). Conclusions In elderly patients with chronic respiratory disease, the measurement of pulmonary diffuse function is a more sensitive indicator and often changes before other abnormalities in pulmonary function tests.