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目的评价脱亚胺基重组大鼠聚微丝蛋白抗体(ArFA)在类风湿关节炎(RA)诊断中的应用价值。方法分别测定了190例RA患者和150例其他患者的ArFA,以及196例RA患者和207例其他患者的抗环瓜氨酸肽(CCP)抗体,并分析了两种抗体诊断RA的敏感性、特异性、阴性预测值与阳性预测值。结果ArFA的敏感性、特异性、阳性预测值、阴性预测值分别为77.9%、93.3%、93.7%、76.9%;而抗CCP抗体的敏感性、特异性、阳性预测值、阴性预测值分别为67.9%、94.7%、92.4%、75.7%;ArFA的敏感性高于抗CCP抗体(P<0.05)。结论ArFA可作为RA诊断手段的补充,其较高的敏感性源于结构上的脱亚胺基。
Objective To evaluate the value of Arf in recombinant deiminated rats in the diagnosis of rheumatoid arthritis (RA). Methods The anti-cyclic citrullinated peptide (CCP) antibodies of 190 patients with RA and 150 patients with other RAFA were measured. Anti-cyclic citrullinated peptide (CCP) antibodies were also detected in 196 patients with RA and 207 patients with other RA. Specificity, negative predictive value and positive predictive value. Results The sensitivity, specificity, positive predictive value and negative predictive value of ArFA were 77.9%, 93.3%, 93.7% and 76.9%, respectively. The sensitivity, specificity, positive predictive value and negative predictive value of anti-CCP antibody were 67.9%, 94.7%, 92.4%, 75.7%, respectively. The sensitivity of ArFA was higher than that of anti-CCP antibody (P <0.05). Conclusion ArFA can be used as a diagnostic tool for RA, its higher sensitivity derived from the structural deimino.