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目的:探讨泮托拉唑治疗十二指肠球部溃疡的近期疗效。方法:70例十二指肠球部溃疡患者随机分成2组,各35例,分别服用泮托拉唑片剂40 mg及兰索拉唑胶囊30 mg,每日一次,疗程4周。结果:泮托拉唑组和兰索拉唑组溃疡愈合率分别为91.4％及94.3％,总有效率均为100％。两组无显著差异(P>0.05)。但在缓解疼痛症状上泮托拉唑比兰索拉唑更迅速,两者有显著差异(P<0.05)。结论:泮托拉唑治疗十二指肠球部溃疡有很好的近期疗效,且不良反应少。
Objective: To investigate the short-term efficacy of pantoprazole in the treatment of duodenal ulcer. Methods: Seventy patients with duodenal ulcer were randomly divided into 2 groups (n = 35). The patients were given pantoprazole 40 mg and lansoprazole 30 mg once daily for 4 weeks. Results: The ulcer healing rates in the pantoprazole group and the lansoprazole group were 91.4% and 94.3%, respectively, with a total effective rate of 100%. There was no significant difference between the two groups (P> 0.05). However, pantoprazole was more effective than lansoprazole in relieving pain symptoms, with significant difference (P <0.05). Conclusions: Pantoprazole has a good short-term curative effect in the treatment of duodenal ulcer with few adverse reactions.