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目的分析阿奇霉素治疗儿童呼吸道感染的疗效及安全性。方法 112例呼吸道感染患儿,随机分成对照组和观察组,各56例。对照组给予红霉素治疗,观察组给予阿奇霉素治疗,观察两组患儿临床疗效及不良反应发生率。结果治疗后,对照组痊愈19例,有效22例,无效15例;观察组痊愈33例,有效20例,无效3例。观察组总有效率94.64%明显高于对照组的73.21%,差异具有统计学意义(P<0.05)。对照组出现恶心5例、腹痛3例、发热4例,不良反应发生率为21.43%(12/56);观察组出现恶心1例、腹痛2例,不良反应发生率为5.36%(3/56)。观察组不良反应发生率明显低于对照组,差异具有统计学意义(P<0.05)。结论阿奇霉素治疗儿童呼吸道感染具有良好的疗效及安全性,副作用较小,值得在临床上推广应用。
Objective To analyze the efficacy and safety of azithromycin in the treatment of respiratory tract infections in children. Methods A total of 112 children with respiratory tract infection were randomly divided into control group and observation group, with 56 cases in each group. The control group was treated with erythromycin, and the observation group was treated with azithromycin. The clinical efficacy and the incidence of adverse reactions in both groups were observed. Results After treatment, 19 cases were cured in the control group, 22 cases were effective and 15 cases were ineffective. The observation group was cured in 33 cases, effective in 20 cases and ineffective in 3 cases. The total effective rate in the observation group was 94.64%, which was significantly higher than that in the control group (73.21%), the difference was statistically significant (P <0.05). In the control group, nausea occurred in 5 cases, abdominal pain in 3 cases and fever in 4 cases, the incidence of adverse reactions was 21.43% (12/56). In the observation group, nausea occurred in 1 case and abdominal pain in 2 cases. The incidence of adverse reactions was 5.36% ). The incidence of adverse reactions in the observation group was significantly lower than that in the control group, the difference was statistically significant (P <0.05). Conclusion Azithromycin has a good curative effect and safety in the treatment of children’s respiratory tract infection, with less side effects and is worth popularizing and applying in clinic.