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脂肪酸是心脏主要供能物质,占心脏能源的40—80%。安静情况下,脂肪酸氧化占心脏总氧耗量的80%。但是过多的脂肪酸在心脏堆积会抑制心肌收缩力,诱发心率失常和抑制线粒体氧化磷酸化和ATP—Pi 转换,可损伤心肌细胞完整性使乳酸脱氢酶、肌酸激酶等从细胞释出造成心脏损害。正常和疾病时心脏脂肪酸代谢的复杂性一直受到人们的关注。1986年第一届正常和缺血心脏脂质代谢国际研讨会在鹿特丹召开引起与会者极大兴趣。紧接着1988年又在荷兰Maas-tricht 举行第二次研讨会。本文就这次会议有关问题及近年来心脏脂肪酸代谢的研究进展作一介绍。
Fatty acids are the main energy supply of the heart, accounting for 40-80% of the heart energy. Under quiet conditions, fatty acid oxidation accounts for 80% of the total heart oxygen consumption. However, excessive accumulation of fatty acids in the heart inhibits myocardial contractility, induces arrhythmia and inhibits mitochondrial oxidative phosphorylation and ATP-Pi switching, which can impair cardiomyocyte integrity and release lactate dehydrogenase and creatine kinase from cells Heart damage. The complexity of fatty acid metabolism in the heart during normal and disease conditions has drawn attention. The first International Symposium on Normal and Ischemic Cardiac Lipid Metabolism held in Rotterdam in 1986 aroused great interest among participants. This was followed by a second seminar in Maastricht, the Netherlands in 1988. In this paper, the meeting on the issues and recent research on cardiac fatty acid metabolism to make an introduction.