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[目的]探讨早产儿脑室周围白质软化(PVL)发生的高危因素。[方法]对某院近两年576例早产儿诊疗过程中存在的多种危险因素进行分析。[结果]576例早产儿确诊患早产儿脑周围白质软化139例,发生率为24.1%。与胎龄、体重、重度窒息、呼吸支持、围生期/出生早期感染等多种因素密切相关。[结论]PVL治病因素复杂,重度窒息、呼吸支持、围生期/出生早期感染、颅内出血是早产儿PVL发生的主要高危因素。
[Objective] To explore the risk factors of periventricular leukomalacia (PVL) in preterm infants. [Methods] A variety of risk factors existed in the treatment of 576 premature infants in a hospital during the past two years were analyzed. [Results] 139 cases of white matter softening in preterm infants were diagnosed in 576 premature infants, the incidence was 24.1%. And gestational age, weight, severe asphyxia, respiratory support, perinatal / early infection and other factors are closely related. [Conclusion] Complication of PVL, severe suffocation, respiratory support, early perinatal / early stage infection and intracranial hemorrhage are the main risk factors of PVL in preterm infants.